A PEPTIDE-BASED HIV-1 FUSION INHIBITOR WITH TWO TAIL-ANCHORS AND PALMITIC ACID EXHIBITS SUBSTANTIALLY IMPROVED IN VITRO AND EX VIVO ANTI-HIV-1 ACTIVITY AND PROLONGED IN VIVO HALF-LIFE

Enfuvirtide (T20) is the first U.S.FDA-approved HIV fusion inhibitor-based anti-HIV drug.Its clinical application is limited because of its low potency and short half-life.We Rangefinder previously reported that peptide HP23-E6-IDL, containing both N- and C-terminal anchor-tails, exhibited stronger potency and a better resistance profile than T20.H

Background: An electrical storm due to malignant ventricular tachycardia (VT) is a life-threatening condition that requires catheter ablation (CA).Most VT arrhythmias evolve over time after acute myocardial infarction, coronary artery bypass grafting, or chronic heart failure.Clinically, only radiofrequency ablation can identify and block all arrhy

Modern onboard equipment complexes (OEC) utilize AFDX and FC-AE-ASM-RT switched networks implementing a virtual link-based approach to real-time data transfer.The main drawback of these networks is their limited or absent support for dynamic reconfiguration of virtual links, which makes impossible the dynamical Bedding recomposition of OEC operatio

Pterodactyloid pterosaurs are widely interpreted as terrestrially competent, erect-limbed quadrupeds, but the terrestrial capabilities of non-pterodactyloids are largely thought to have been Eye Creams poor.This is commonly justified by the absence of a non-pterodactyloid footprint record, suggestions that the expansive uropatagia common to early p